The properties of topological materials have to be manipulated to realize the topological quantum computation. In my talk, several examples are given to show how to use the temperature, strain, magnetic field and proximity effect to tune the properties of the topological materials. Keywords: topological insulators, topological superconductor, Majorana zero mode, topological quantum computation, STM/STS1. G. Wang, et al., Adv. Mater. 23(26), 2929 (2011)2. C. Liu, et al., Phys. Rev. Lett. 126, 176102 (2021)3. Z. Zhu, et al., Science (2021). DOI:10.1126/science.abf10774. C. X. Zhao, et al., Phys. Rev. Lett. 125, 046801 (2020)5. M. X. Wang, et al., Science 336, 52-55 (2012).6. J. P. Xu, et al., Phys. Rev. Lett. 112, 217001 (2014).7. J. P. Xu, et al., Phys. Rev. Lett. 114, 017001 (2015).8. H. H Sun, et al., Phys. Rev. Lett. 116, 257003 (2016)9. H. H. Sun, Jin-Feng Jia, NPJ Quan. Mater. 2, 34 (2017)10. H. Yang, et al., Adv. Mater. 31, 1905582 (2019), Phys. Rev. Lett. 125, 136802 (2020).